N177Y (p.Asn177Tyr) variant of TLR9 (Toll-like receptor 9)
N177Y (p.Asn177Tyr) in TLR9 (Toll-like receptor 9) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
N177Y (p.Asn177Tyr) variant details
- p.Asn177Tyr
- TOPMed rs1192636526
- gnomAD rs1192636526
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.54
- REVEL 0.47
- CADD 25.90
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available