M58V (p.Met58Val) variant of TLR9 (Toll-like receptor 9)
M58V (p.Met58Val) in TLR9 (Toll-like receptor 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
M58V (p.Met58Val) variant details
- p.Met58Val
- rs750403100
- NCI-TCGA Cosmic COSV5972
- TOPMed rs750403100
- gnomAD rs750403100
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.15
- REVEL 0.06
- CADD 4.69
- PolyPhen-2 0.00
- SIFT 0.10
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 5.1e-05)
- Structural context available