M22I (p.Met22Ile) variant of TLR9 (Toll-like receptor 9)
M22I (p.Met22Ile) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data and structural context.
M22I (p.Met22Ile) variant details
- p.Met22Ile
- TOPMed rs1241708543
- gnomAD rs1241708543
- Missense
- Variant Prioritization Score for Impact Estimate 0.186
- REVEL 0.05
- CADD 5.70
- PolyPhen-2 0.00
- SIFT 0.18
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available