L70S (p.Leu70Ser) variant of TLR9 (Toll-like receptor 9)
L70S (p.Leu70Ser) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
L70S (p.Leu70Ser) variant details
- p.Leu70Ser
- ExAC rs756551977
- gnomAD rs756551977
- Missense
- Variant Prioritization Score for Impact Estimate 0.573
- REVEL 0.53
- CADD 24.90
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.4e-05)
- Structural context available