L166P (p.Leu166Pro) variant of TLR9 (Toll-like receptor 9)
L166P (p.Leu166Pro) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
L166P (p.Leu166Pro) variant details
- p.Leu166Pro
- ExAC rs771634375
- gnomAD rs771634375
- Missense
- Variant Prioritization Score for Impact Estimate 0.475
- REVEL 0.44
- CADD 23.60
- PolyPhen-2 1.00
- SIFT 0.04
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available