L156P (p.Leu156Pro) variant of TLR9 (Toll-like receptor 9)
L156P (p.Leu156Pro) in TLR9 (Toll-like receptor 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
L156P (p.Leu156Pro) variant details
- p.Leu156Pro
- rs1224643512
- TOPMed rs1224643512
- gnomAD rs1224643512
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.44
- REVEL 0.31
- CADD 23.20
- PolyPhen-2 0.96
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available