L148M (p.Leu148Met) variant of TLR9 (Toll-like receptor 9)
L148M (p.Leu148Met) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
L148M (p.Leu148Met) variant details
- p.Leu148Met
- TOPMed rs1424057961
- Missense
- Variant Prioritization Score for Impact Estimate 0.453
- REVEL 0.35
- CADD 23.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 0.00029)
- Structural context available