L120S (p.Leu120Ser) variant of TLR9 (Toll-like receptor 9)
L120S (p.Leu120Ser) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
L120S (p.Leu120Ser) variant details
- p.Leu120Ser
- gnomAD rs1699593912
- Missense
- Variant Prioritization Score for Impact Estimate 0.258
- REVEL 0.18
- CADD 19.70
- PolyPhen-2 0.47
- SIFT 0.26
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available