K181N (p.Lys181Asn) variant of TLR9 (Toll-like receptor 9)
K181N (p.Lys181Asn) in TLR9 (Toll-like receptor 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
K181N (p.Lys181Asn) variant details
- p.Lys181Asn
- rs1438595607
- NCI-TCGA Cosmic COSV1005
- TOPMed rs1438595607
- gnomAD rs1438595607
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.295
- REVEL 0.12
- CADD 21.90
- PolyPhen-2 0.55
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available