I135V (p.Ile135Val) variant of TLR9 (Toll-like receptor 9)
I135V (p.Ile135Val) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
I135V (p.Ile135Val) variant details
- p.Ile135Val
- ExAC rs761364189
- gnomAD rs761364189
- Missense
- Variant Prioritization Score for Impact Estimate 0.231
- REVEL 0.10
- CADD 18.40
- PolyPhen-2 0.09
- SIFT 0.01
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available