H85Y (p.His85Tyr) variant of TLR9 (Toll-like receptor 9)
H85Y (p.His85Tyr) in TLR9 (Toll-like receptor 9) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
H85Y (p.His85Tyr) variant details
- p.His85Tyr
- rs201646083
- ClinGen CA2430855
- ClinVar RCV004472459
- ExAC rs201646083
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.151
- REVEL 0.09
- CADD 8.98
- PolyPhen-2 0.01
- SIFT 0.81
- ClinVar: Uncertain significance (not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the HGDP:SARDINIAN population (allele frequency 0.019)
- Structural context available