G165S (p.Gly165Ser) variant of TLR9 (Toll-like receptor 9)
G165S (p.Gly165Ser) in TLR9 (Toll-like receptor 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
G165S (p.Gly165Ser) variant details
- p.Gly165Ser
- rs201740851
- NCI-TCGA Cosmic COSV5972
- ExAC rs201740851
- TOPMed rs201740851
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- REVEL 0.16
- CADD 17.80
- PolyPhen-2 0.97
- SIFT 0.03
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available