C98Y (p.Cys98Tyr) variant of TLR9 (Toll-like receptor 9)
C98Y (p.Cys98Tyr) in TLR9 (Toll-like receptor 9) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.55 / 1. The record also includes population frequency data and structural context.
C98Y (p.Cys98Tyr) variant details
- p.Cys98Tyr
- rs773699082
- NCI-TCGA Cosmic COSV1005
- ExAC rs773699082
- gnomAD rs773699082
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.547
- REVEL 0.38
- CADD 24.60
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 2.3e-05)
- Structural context available