A121T (p.Ala121Thr) variant of TLR9 (Toll-like receptor 9)
A121T (p.Ala121Thr) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
A121T (p.Ala121Thr) variant details
- p.Ala121Thr
- 1000Genomes rs149110022
- ExAC rs149110022
- TOPMed rs149110022
- gnomAD rs149110022
- Missense
- Variant Prioritization Score for Impact Estimate 0.318
- REVEL 0.03
- CADD 15.40
- PolyPhen-2 0.34
- SIFT 0.15
- Most common in the Non-Finnish European population (allele frequency 4.4e-05)
- Structural context available