A121S (p.Ala121Ser) variant of TLR9 (Toll-like receptor 9)
A121S (p.Ala121Ser) in TLR9 (Toll-like receptor 9) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
A121S (p.Ala121Ser) variant details
- p.Ala121Ser
- 1000Genomes rs149110022
- ExAC rs149110022
- TOPMed rs149110022
- gnomAD rs149110022
- Missense
- Variant Prioritization Score for Impact Estimate 0.3
- REVEL 0.02
- CADD 12.80
- PolyPhen-2 0.16
- SIFT 0.28
- Most common in the 1KG:TSI population (allele frequency 0.0049)
- Structural context available