V45I (p.Val45Ile) variant of TLR8 (Toll-like receptor 8)
V45I (p.Val45Ile) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data and structural context.
V45I (p.Val45Ile) variant details
- p.Val45Ile
- ExAC rs766470317
- TOPMed rs766470317
- gnomAD rs766470317
- Missense
- Variant Prioritization Score for Impact Estimate 0.0732
- REVEL 0.02
- MetaLR 0.07
- MetaSVM -1.05
- CADD 0.07
- PolyPhen-2 0.01
- SIFT 0.90
- Most common in the Latino/Admixed American population (allele frequency 0.00028)
- Structural context available