T90I (p.Thr90Ile) variant of TLR8 (Toll-like receptor 8)
T90I (p.Thr90Ile) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, published literature, and structural context.
T90I (p.Thr90Ile) variant details
- p.Thr90Ile
- gnomAD X-12919309-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.253
- REVEL 0.19
- MetaLR 0.23
- MetaSVM -0.89
- CADD 15.70
- PolyPhen-2 0.86
- SIFT 0.07
- Most common in the South Asian population (allele frequency 1.8e-05)
- Structural context available
- Literature evidence available