T66I (p.Thr66Ile) variant of TLR8 (Toll-like receptor 8)
T66I (p.Thr66Ile) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, published literature, and structural context.
T66I (p.Thr66Ile) variant details
- p.Thr66Ile
- gnomAD X-12919237-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.472
- REVEL 0.50
- MetaLR 0.37
- MetaSVM -0.22
- CADD 23.30
- SIFT 0.03
- Most common in the REMAINING population (allele frequency 0.00066)
- Structural context available
- Literature evidence available