S19F (p.Ser19Phe) variant of TLR8 (Toll-like receptor 8)
S19F (p.Ser19Phe) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data and structural context.
S19F (p.Ser19Phe) variant details
- p.Ser19Phe
- TOPMed rs2043074994
- gnomAD rs2043074994
- Missense
- Variant Prioritization Score for Impact Estimate 0.128
- REVEL 0.04
- MetaLR 0.06
- MetaSVM -1.06
- CADD 7.53
- SIFT 0.65
- Most common in the African/African-American population (allele frequency 3.2e-05)
- Structural context available