R53Q (p.Arg53Gln) variant of TLR8 (Toll-like receptor 8)
R53Q (p.Arg53Gln) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
R53Q (p.Arg53Gln) variant details
- p.Arg53Gln
- TOPMed rs1352055700
- gnomAD rs1352055700
- Missense
- Variant Prioritization Score for Impact Estimate 0.0957
- REVEL 0.04
- MetaLR 0.05
- MetaSVM -1.06
- CADD 8.27
- PolyPhen-2 0.05
- SIFT 0.32
- Most common in the South Asian population (allele frequency 5.5e-05)
- Structural context available