P58L (p.Pro58Leu) variant of TLR8 (Toll-like receptor 8)
P58L (p.Pro58Leu) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data, published literature, and structural context.
P58L (p.Pro58Leu) variant details
- p.Pro58Leu
- gnomAD X-12919213-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.586
- REVEL 0.57
- MetaLR 0.36
- MetaSVM -0.23
- CADD 24.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 2.4e-06)
- Structural context available
- Literature evidence available