M4T (p.Met4Thr) variant of TLR8 (Toll-like receptor 8)
M4T (p.Met4Thr) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
M4T (p.Met4Thr) variant details
- p.Met4Thr
- gnomAD X-12919051-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.322
- REVEL 0.20
- MetaLR 0.06
- MetaSVM -0.98
- CADD 23.30
- PolyPhen-2 0.46
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 2.4e-06)
- Structural context available
- Literature evidence available