M4K (p.Met4Lys) variant of TLR8 (Toll-like receptor 8)
M4K (p.Met4Lys) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
M4K (p.Met4Lys) variant details
- p.Met4Lys
- ExAC rs780074989
- TOPMed rs780074989
- gnomAD rs780074989
- Missense
- Variant Prioritization Score for Impact Estimate 0.328
- REVEL 0.22
- MetaLR 0.05
- MetaSVM -1.07
- CADD 22.60
- PolyPhen-2 0.24
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 4.4e-05)
- Structural context available