L86P (p.Leu86Pro) variant of TLR8 (Toll-like receptor 8)
L86P (p.Leu86Pro) in TLR8 (Toll-like receptor 8) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
L86P (p.Leu86Pro) variant details
- p.Leu86Pro
- TOPMed rs1379157437
- gnomAD rs1379157437
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.564
- REVEL 0.58
- MetaLR 0.64
- MetaSVM -0.06
- CADD 24.90
- PolyPhen-2 0.98
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 3.8e-05)
- Structural context available