L6F (p.Leu6Phe) variant of TLR8 (Toll-like receptor 8)
L6F (p.Leu6Phe) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, published literature, and structural context.
L6F (p.Leu6Phe) variant details
- p.Leu6Phe
- gnomAD X-12919056-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.119
- REVEL 0.02
- MetaLR 0.06
- MetaSVM -1.01
- CADD 4.63
- PolyPhen-2 0.01
- SIFT 0.09
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- Literature evidence available