L68P (p.Leu68Pro) variant of TLR8 (Toll-like receptor 8)
L68P (p.Leu68Pro) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.65 / 1. The record also includes population frequency data and structural context.
L68P (p.Leu68Pro) variant details
- p.Leu68Pro
- cosmic curated COSV54320
- Missense
- Variant Prioritization Score for Impact Estimate 0.647
- REVEL 0.67
- MetaLR 0.81
- MetaSVM 0.57
- CADD 24.50
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the Finnish in Finland (FIN) population (allele frequency 2.5e-05)
- Structural context available