K91I (p.Lys91Ile) variant of TLR8 (Toll-like receptor 8)
K91I (p.Lys91Ile) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, published literature, and structural context.
K91I (p.Lys91Ile) variant details
- p.Lys91Ile
- gnomAD X-12919312-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.223
- REVEL 0.16
- MetaLR 0.11
- MetaSVM -0.97
- CADD 17.90
- PolyPhen-2 0.64
- SIFT 0.17
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- Literature evidence available