K91E (p.Lys91Glu) variant of TLR8 (Toll-like receptor 8)
K91E (p.Lys91Glu) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
K91E (p.Lys91Glu) variant details
- p.Lys91Glu
- ExAC rs773370542
- gnomAD rs773370542
- Missense
- Variant Prioritization Score for Impact Estimate 0.211
- REVEL 0.14
- MetaLR 0.06
- MetaSVM -0.94
- CADD 15.70
- PolyPhen-2 0.34
- SIFT 0.09
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available