I78T (p.Ile78Thr) variant of TLR8 (Toll-like receptor 8)
I78T (p.Ile78Thr) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, published literature, and structural context.
I78T (p.Ile78Thr) variant details
- p.Ile78Thr
- gnomAD X-12919273-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.377
- REVEL 0.25
- MetaLR 0.44
- MetaSVM -0.49
- CADD 23.50
- PolyPhen-2 0.91
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 5.9e-06)
- Structural context available
- Literature evidence available