H77R (p.His77Arg) variant of TLR8 (Toll-like receptor 8)
H77R (p.His77Arg) in TLR8 (Toll-like receptor 8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
H77R (p.His77Arg) variant details
- p.His77Arg
- rs745722261
- NCI-TCGA Cosmic COSV5431
- cosmic curated COSV54319
- ExAC rs745722261
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.102
- REVEL 0.08
- MetaLR 0.07
- MetaSVM -1.00
- CADD 0.33
- PolyPhen-2 0.00
- SIFT 0.60
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available