H77Q (p.His77Gln) variant of TLR8 (Toll-like receptor 8)
H77Q (p.His77Gln) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.08 / 1. The record also includes population frequency data and structural context.
H77Q (p.His77Gln) variant details
- p.His77Gln
- cosmic curated COSV54317
- ExAC rs771849849
- gnomAD rs771849849
- Missense
- Variant Prioritization Score for Impact Estimate 0.0804
- REVEL 0.04
- MetaLR 0.07
- MetaSVM -1.04
- CADD 0.33
- PolyPhen-2 0.01
- SIFT 0.46
- Most common in the Non-Finnish European population (allele frequency 2.4e-06)
- Structural context available