G20S (p.Gly20Ser) variant of TLR8 (Toll-like receptor 8)
G20S (p.Gly20Ser) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data, published literature, and structural context.
G20S (p.Gly20Ser) variant details
- p.Gly20Ser
- gnomAD X-12919098-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.141
- REVEL 0.07
- MetaLR 0.05
- MetaSVM -1.11
- CADD 6.13
- PolyPhen-2 0.11
- SIFT 0.48
- Most common in the South Asian population (allele frequency 1.9e-05)
- Structural context available
- Literature evidence available