G20C (p.Gly20Cys) variant of TLR8 (Toll-like receptor 8)
G20C (p.Gly20Cys) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
G20C (p.Gly20Cys) variant details
- p.Gly20Cys
- cosmic curated COSV99487
- ExAC rs777353095
- gnomAD rs777353095
- Missense
- Variant Prioritization Score for Impact Estimate 0.135
- REVEL 0.04
- MetaLR 0.07
- MetaSVM -1.03
- CADD 9.39
- PolyPhen-2 0.02
- SIFT 0.31
- Most common in the Non-Finnish European population (allele frequency 5.9e-06)
- Structural context available