F74V (p.Phe74Val) variant of TLR8 (Toll-like receptor 8)
F74V (p.Phe74Val) in TLR8 (Toll-like receptor 8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
F74V (p.Phe74Val) variant details
- p.Phe74Val
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.0913
- REVEL 0.02
- MetaLR 0.06
- MetaSVM -1.03
- CADD 7.86
- PolyPhen-2 0.25
- SIFT 0.49
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available