E38G (p.Glu38Gly) variant of TLR8 (Toll-like receptor 8)
E38G (p.Glu38Gly) in TLR8 (Toll-like receptor 8) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
E38G (p.Glu38Gly) variant details
- p.Glu38Gly
- NCI-TCGA Cosmic COSV5431
- cosmic curated COSV54318
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.176
- REVEL 0.06
- MetaLR 0.07
- MetaSVM -1.05
- CADD 17.80
- PolyPhen-2 0.42
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available