E28Q (p.Glu28Gln) variant of TLR8 (Toll-like receptor 8)
E28Q (p.Glu28Gln) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
E28Q (p.Glu28Gln) variant details
- p.Glu28Gln
- cosmic curated COSV10957
- Missense
- Variant Prioritization Score for Impact Estimate 0.0945
- REVEL 0.01
- MetaLR 0.05
- MetaSVM -1.02
- CADD 0.22
- PolyPhen-2 0.07
- SIFT 0.57
- Most common in the REMAINING population (allele frequency 4.3e-05)
- Structural context available