E28K (p.Glu28Lys) variant of TLR8 (Toll-like receptor 8)
E28K (p.Glu28Lys) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
E28K (p.Glu28Lys) variant details
- p.Glu28Lys
- TOPMed rs1435069623
- gnomAD rs1435069623
- Missense
- Variant Prioritization Score for Impact Estimate 0.101
- REVEL 0.02
- MetaLR 0.04
- MetaSVM -1.00
- CADD 0.27
- PolyPhen-2 0.00
- SIFT 0.90
- Most common in the African/African-American population (allele frequency 9.8e-05)
- Structural context available