D37E (p.Asp37Glu) variant of TLR8 (Toll-like receptor 8)
D37E (p.Asp37Glu) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
D37E (p.Asp37Glu) variant details
- p.Asp37Glu
- ExAC rs777910070
- TOPMed rs777910070
- gnomAD rs777910070
- Missense
- Variant Prioritization Score for Impact Estimate 0.114
- REVEL 0.10
- MetaLR 0.12
- MetaSVM -0.95
- CADD 0.65
- PolyPhen-2 0.76
- SIFT 0.04
- Most common in the Latino/Admixed American population (allele frequency 9.4e-05)
- Structural context available