C13Y (p.Cys13Tyr) variant of TLR8 (Toll-like receptor 8)
C13Y (p.Cys13Tyr) in TLR8 (Toll-like receptor 8) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
C13Y (p.Cys13Tyr) variant details
- p.Cys13Tyr
- ExAC rs747672778
- gnomAD rs747672778
- Missense
- Variant Prioritization Score for Impact Estimate 0.313
- REVEL 0.11
- MetaLR 0.04
- MetaSVM -1.02
- CADD 7.24
- PolyPhen-2 0.00
- SIFT 0.09
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available