W6G (p.Trp6Gly) variant of TLR7 (Toll-like receptor 7)
W6G (p.Trp6Gly) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data, published literature, and structural context.
W6G (p.Trp6Gly) variant details
- p.Trp6Gly
- gnomAD X-12885524-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.237
- REVEL 0.09
- MetaLR 0.07
- MetaSVM -1.05
- CADD 14.40
- PolyPhen-2 0.00
- SIFT 0.09
- Most common in the Latino/Admixed American population (allele frequency 2.9e-05)
- Structural context available
- Literature evidence available