T7P (p.Thr7Pro) variant of TLR7 (Toll-like receptor 7)
T7P (p.Thr7Pro) in TLR7 (Toll-like receptor 7) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not provided. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
T7P (p.Thr7Pro) variant details
- p.Thr7Pro
- Ensembl rs781486181
- Uncertain significance
- not provided
- Missense
- Variant Prioritization Score for Impact Estimate 0.268
- REVEL 0.17
- MetaLR 0.09
- MetaSVM -1.03
- CADD 12.80
- PolyPhen-2 0.12
- SIFT 0.10
- ClinVar: Uncertain significance (not provided)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 1.9e-05)
- Structural context available