T68P (p.Thr68Pro) variant of TLR7 (Toll-like receptor 7)
T68P (p.Thr68Pro) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data, published literature, and structural context.
T68P (p.Thr68Pro) variant details
- p.Thr68Pro
- gnomAD X-12885710-A-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.523
- REVEL 0.54
- MetaLR 0.38
- MetaSVM -0.15
- CADD 23.70
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- Literature evidence available