T65M (p.Thr65Met) variant of TLR7 (Toll-like receptor 7)
T65M (p.Thr65Met) in TLR7 (Toll-like receptor 7) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
T65M (p.Thr65Met) variant details
- p.Thr65Met
- rs200329031
- NCI-TCGA Cosmic COSV6612
- TOPMed rs200329031
- gnomAD rs200329031
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.149
- REVEL 0.07
- MetaLR 0.13
- MetaSVM -0.84
- CADD 7.05
- PolyPhen-2 0.02
- SIFT 0.08
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3.3e-05)
- Structural context available