R10G (p.Arg10Gly) variant of TLR7 (Toll-like receptor 7)
R10G (p.Arg10Gly) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
R10G (p.Arg10Gly) variant details
- p.Arg10Gly
- TOPMed rs1490750885
- Missense
- Variant Prioritization Score for Impact Estimate 0.169
- REVEL 0.07
- MetaLR 0.08
- MetaSVM -1.02
- CADD 15.20
- PolyPhen-2 0.05
- SIFT 0.10
- Most common in the African/African-American population (allele frequency 3.8e-05)
- Structural context available