P4L (p.Pro4Leu) variant of TLR7 (Toll-like receptor 7)
P4L (p.Pro4Leu) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data and structural context.
P4L (p.Pro4Leu) variant details
- p.Pro4Leu
- gnomAD rs1258108007
- Missense
- Variant Prioritization Score for Impact Estimate 0.256
- REVEL 0.05
- MetaLR 0.08
- MetaSVM -1.01
- CADD 2.42
- PolyPhen-2 0.15
- SIFT 0.28
- Most common in the East Asian population (allele frequency 3.3e-05)
- Structural context available