N110S (p.Asn110Ser) variant of TLR7 (Toll-like receptor 7)
N110S (p.Asn110Ser) in TLR7 (Toll-like receptor 7) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
N110S (p.Asn110Ser) variant details
- p.Asn110Ser
- NCI-TCGA Cosmic COSV1010
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.173
- REVEL 0.14
- MetaLR 0.08
- MetaSVM -1.03
- CADD 2.56
- PolyPhen-2 0.01
- SIFT 0.27
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.8e-05)
- Structural context available