M5V (p.Met5Val) variant of TLR7 (Toll-like receptor 7)
M5V (p.Met5Val) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.06 / 1. The record also includes population frequency data and structural context.
M5V (p.Met5Val) variant details
- p.Met5Val
- TOPMed rs1480048433
- gnomAD rs1480048433
- Missense
- Variant Prioritization Score for Impact Estimate 0.063
- REVEL 0.01
- MetaLR 0.06
- MetaSVM -1.03
- CADD 0.00
- PolyPhen-2 0.00
- SIFT 0.28
- Most common in the African/African-American population (allele frequency 3.2e-05)
- Structural context available