M5L (p.Met5Leu) variant of TLR7 (Toll-like receptor 7)
M5L (p.Met5Leu) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.07 / 1. The record also includes population frequency data and structural context.
M5L (p.Met5Leu) variant details
- p.Met5Leu
- TOPMed rs1480048433
- gnomAD rs1480048433
- Missense
- Variant Prioritization Score for Impact Estimate 0.0703
- REVEL 0.03
- MetaLR 0.05
- MetaSVM -1.03
- CADD 0.00
- PolyPhen-2 0.01
- SIFT 0.46
- Most common in the African/African-American population (allele frequency 3.9e-05)
- Structural context available