L25P (p.Leu25Pro) variant of TLR7 (Toll-like receptor 7)
L25P (p.Leu25Pro) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
L25P (p.Leu25Pro) variant details
- p.Leu25Pro
- gnomAD rs1354435927
- Missense
- Variant Prioritization Score for Impact Estimate 0.213
- REVEL 0.09
- MetaLR 0.10
- MetaSVM -1.00
- CADD 8.61
- PolyPhen-2 0.01
- SIFT 0.08
- Most common in the Latino/Admixed American population (allele frequency 2.8e-05)
- Structural context available