L25F (p.Leu25Phe) variant of TLR7 (Toll-like receptor 7)
L25F (p.Leu25Phe) in TLR7 (Toll-like receptor 7) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
L25F (p.Leu25Phe) variant details
- p.Leu25Phe
- gnomAD X-12885581-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.208
- REVEL 0.02
- MetaLR 0.09
- MetaSVM -1.01
- CADD 8.49
- PolyPhen-2 0.01
- SIFT 0.14
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available
- Literature evidence available